digitalis

DIGITALIS

·         Digitalis acts in atrial fibrillation by:- Increase in AV node refractoriness.

·         Major electrophysiological effect of digitalis is: 1) hyperpolarization

                                                                                                   2) shortening of atrial action potential

                                                                                                   3) increase in AV node refractoriness.

·         Increase in AV node refractoriness is also responsive for termination of reentrant arrhythmias involving the AV node.

·         Inhibition of Na⁺  K⁺ ATPase is responsible for inotropic action of digitalis.

 

ANTIANDROGENS:- Danazol , Cyproterone acetate , Flutamide

ANTIESTROGEN:-Clomiphene citrate , Tamoxifen citrate

ANTIPROGESTINS:-Mifepristone (RU486)

 

Even in large dosages used in malaria, quinine does not cause toxicity because :-elevates plasma alpha1 acid glycoprotein . About quinine:- ·         It is an erythrocytic schizontocide. ·         Used for t/t of multidrug resistant strains of P.falciparum ·         Associated with a triad of dose related toxicities-  a)cinchonism b)hypotension c)hypoglycemia