Passive immunization procedures with antisera


Passive Immunization (Antisera)


The usual prophylactic dose is 1500 units of horse ATS given s.c. or im. Soon after injury

Gas Gangrene

A polyvalent antitoxin is used. A patient who has sustained a wound possibly contaminated with spores of gas gangrene should receive a dose of 10,000IU of Cl.perfringens. Antitoxin, 5000 units of Cl.septicum antitoxin & 10,000 units of Cl.oedematiens antitoxin, im or in urgent cases intravenously  


Antirabies serum in a dose of of 40 IU per kg of body weight should be given im within 72 hours & preferably within 24 hrs of exposure. A part of the antiserum is applied locally to the wound.


When Botulism is suspected, 10,000 units of polyvalent antitoxin is recommended every 3 to 4 hours


A dose of 500-1,000 unit of diphtheria antitoxin is given im to susceptible contacts immediately after exposure. Protection does not last more than 2-3 weeks.


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