Passive immunization procedures with antisera

Disease	Passive Immunization (Antisera)
Tetanus	The usual prophylactic dose is 1500 units of horse ATS given s.c. or im. Soon after injury
Gas Gangrene	A polyvalent antitoxin is used. A patient who has sustained a wound possibly contaminated with spores of gas gangrene should receive a dose of 10,000IU of Cl.perfringens. Antitoxin, 5000 units of Cl.septicum antitoxin & 10,000 units of Cl.oedematiens antitoxin, im or in urgent cases intravenously
Rabies	Antirabies serum in a dose of of 40 IU per kg of body weight should be given im within 72 hours & preferably within 24 hrs of exposure. A part of the antiserum is applied locally to the wound.
Botulism	When Botulism is suspected, 10,000 units of polyvalent antitoxin is recommended every 3 to 4 hours
Diphtheria	A dose of 500-1,000 unit of diphtheria antitoxin is given im to susceptible contacts immediately after exposure. Protection does not last more than 2-3 weeks.

 

Human filarial infections

	Organism	Vector	Disease produced
1	Wuchereria bancrofti	Culex mosquitoes	Lymphatic filariasis
2	Brugia malayi	Mansonia mosquitoes	Lymphatic filariasis
3	Brugia timori	Anopheles mosquitoes, Mansonia mosquitoes	Lymphatic filariasis
4	Onchocerca volvulus	Simulum flies	Subcutaneous nodules, River blindness
5	Loa loa	Chrysopes flies	Recurrent, Transient subcutaneous swellings
6	T.perstans	Culicoides	Probably rarely any clinical illness
7	T.streptocerca	Culicoides	Probably rarely any clinical illness
8	Mansonella ozzardi	Culicoides	Probably rarely any clinical illness